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1 Covaxin dose to survivor equals 2 doses to uninfected | India News

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NEW DELHI: A single-dose of Bharat Biotech’s Covaxin in people who had been infected with Covid-19 previously generates antibody response similar to that provided by two doses of the vaccine in those without any history of the infection, shows a pilot study by the Indian Council of Medical Research (ICMR).
The findings are based on preliminary data and need to be confirmed with large-sized cohort studies, it said.
The study assumes significance because if ICMR can validate the initial findings through a large-scale study, it can be instrumental in expediting the coverage.
“This study offers evidence in support of public health-oriented and immunologically sustained vaccine strategies. If our preliminary findings are confirmed in large population studies, a single dose of BBV152 vaccine may be recommended to previously confirmed SARS-CoV-2 infected individuals so that the naïve individuals could attain the larger benefit of a limited vaccine supply,” says the short paper with the findings of the study published in the Indian Journal of Medical Research.
However, the authors underlined that both vaccine doses would be ideal even for previously infected individuals in the long run due to the occurrence of variants of concern.
Bharat Biotech’s Covaxin is currently administered in a two-dose regimen with a gap of four to six weeks.
The ICMR study was undertaken to examine SARS-CoV-2–specific antibody responses after day zero (baseline, before vaccination), Day 28 (month 1) and Day 56 post-first dose (month 2) of Covaxin in a group of healthcare professionals as well as front-line workers.
The antibody response of individuals with confirmed pre-vaccination SARS-CoV-2 infection was compared with those individuals without prior evidence of infection.

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August 28, 2021, 10:13 pm





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